562
chapter 24
DNA Replication, Repair, and Mutagenesis
tumor cell. One possibility is that fragile sites are more
susceptible to carcinogenic chemicals and that mutations
in fragile sites contribute to the transformation of a normal
cell to a tumor cell.
Supplemental Readings and References
S. G. Arbuck and C. H. Takimoto: An overview of topoisomerase I-targeting
agents.
Seminar in Hematogy
35(SuppI. 4), 3 (1998).
S. E. Ball, F. M. Gibson, S. Rizzo, et at: Progressive telomere shortening in
aplastic anemia.
Blood
91, 3582 (1998).
V. A. Bohr: Gene specific DNA repair.
Carcinogenesis
12, 1983 (1991).
D. Bootsma: The genetic defect in DNA-repair deficiency syndromes.
European Journal of Cancer
29, 1482 (1993).
C. E. Bronner, S. M. Baker, P. T. Morrison, et at: Mutation in the DNA
mismatch repair gene homologue hMLH 1
is associated with hereditary
non-polyposis colon cancer.
Nature
368, 258 (1994).
C. H. C. M. Buys: Telomeres, telomerase, and cancer.
New England Journal
of Medicine
342 (2000).
J. E. Cleaver: Stopping DNA replication in its tracks.
Science
285,
212(1999).
A. Durr, M. Cossee, Y. Agid, et at: Clinical and genetic abnormalities in
patients with Friedreich’s ataxia.
New England Journal of Medicine
335,
1169(1996).
M. Engelhardt, R. Kumar, J. Albanell, et at: Telomerase regulation, cell
cycle, and telomere stability in primitive hematopoietic cells.
Blood
90,
183 (1997).
M. Fessel: Telomerase and the aging celt
Journal of the American Medical
Association
279, 1732 (1998).
E. C. Friedberg, G. C. Walker, and W. Siede:
DNA Repair and Mutagenesis.
Washington, DC: ASM Press (1995).
M. Grunstein: Histone acetylation in chromatin structure and transcription.
Nature
389, 349 (1007).
J. H. J. Hoeijmakers: Nucleotide excision repair II: from yeast to mammals.
Trends in Genetics
9, 211 (1993).
B. Kremer, P. Goldberg, S. E. Andrew, et at: A worldwide study of the
Huntington disease mutation.
New England Journal of Medicine
330,
1401 (1994).
C. Lengauer, K. W. Kinzler, and B. Vogelstein: Genetic instabilities in human
cancers.
Nature
396, 543 (1998).
T. Lindahl and R. D. Wood: Quuality conntrol by DNA rpair.
Science
286,
1897(1999).
J.-L. Mandel: Breaking the rule of three.
Nature
386, 767 (1997).
D. W. Ross: Cancer: The emerging molecular biology.
Hospital Practice
35,
63 (2000).
S. Smith, I. Giriat, A. Schmitt, et at: Tankyrase, a poly (ADPribose) poly-
merase at human telomeres.
Science
282, 1484 (1998).
T. A. Steitz: DNA polymerises: Structural diversity and common mecha-
nisms.
Journal of Biological Chemistry
274, 17395 (1999).
S. T. Warren: Trinucleotide repetition and fragile X syndrome.
Hospital
Practices
32, 73 (1997).
